Artificial Neural Network Based Channel Equalization

The field of digital data communications has experienced an explosive growth in the last three decade with the growth of internet technologies, high speed and efficient data transmission over communication channel has gained significant importance. The rate of data transmissions over a communication system is limited due to the effects of linear and nonlinear distortion. Linear distortions occure in from of inter-symbol interference (ISI), co-channel interference (CCI) and adjacent channel interference (ACI) in the presence of additive white Gaussian noise. Nonlinear distortions are caused due to the subsystems like amplifiers, modulator and demodulator along with nature of the medium. Some times burst noise occurs in communication system. Different equalization techniques are used to mitigate these effects. Adaptive channel equalizers are used in digital communication systems. The equalizer located at the receiver removes the effects of ISI, CCI, burst noise interference and attempts to recover the transmitted symbols. It has been seen that linear equalizers show poor performance, where as nonlinear equalizer provide superior performance. Artificial neural network based multi layer perceptron (MLP) based equalizers have been used for equalization in the last two decade. The equalizer is a feed-forward network consists of one or more hidden nodes between its input and output layers and is trained by popular error based back propagation (BP) algorithm. However this algorithm suffers from slow convergence rate, depending on the size of network. It has been seen that an optimal equalizer based on maximum a-posterior probability (MAP) criterion can be implemented using Radial basis function (RBF) network. In a RBF equalizer, centres are fixed using K-mean clustering and weights are trained using LMS algorithm. RBF equalizer can mitigate ISI interference effectively providing minimum BER plot. But when the input order is increased the number of centre of the network increases and makes the network more complicated. A RBF network, to mitigate the effects of CCI is very complex with large number of centres. To overcome computational complexity issues, a single neuron based chebyshev neural network (ChNN) and functional link ANN (FLANN) have been proposed. These neural networks are single layer network in which the original input pattern is expanded to a higher dimensional space using nonlinear functions and have capability to provide arbitrarily complex decision regions. More recently, a rank based statistics approach known as Wilcoxon learning method has been proposed for signal processing application. The Wilcoxon learning algorithm has been applied to neural networks like Wilcoxon Multilayer Perceptron Neural Network (WMLPNN), Wilcoxon Generalized Radial Basis Function Network (WGRBF). The Wilcoxon approach provides promising methodology for many machine learning problems. This motivated us to introduce these networks in the field of channel equalization application. In this thesis we have used WMLPNN and WGRBF network to mitigate ISI, CCI and burst noise interference. It is observed that the equalizers trained with Wilcoxon learning algorithm offers improved performance in terms of convergence characteristic and bit error rate performance in comparison to gradient based training for MLP and RBF. Extensive simulation studies have been carried out to validate the proposed technique. The performance of Wilcoxon networks is better then linear equalizers trained with LMS and RLS algorithm and RBF equalizer in the case of burst noise and CCI mitigations

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field